Difference Between Fibroblast and Fibrocyte

Main Difference – Fibroblast vs fibrocyte

Fibroblast and fibrocyte are two stages of a fiber-producing cell found in the connective tissues. Fibroblast and fibrocyte differ in morphology, activeness, and biological function in the body. The main difference between fibroblast and fibrocyte is that fibroblast is a large, flat cell with an oval-shaped nucleus involved in the secretion of the extracellular matrix, collagen, and other extracellular macromolecules whereas fibrocyte is a small cell and is the inactive form of the fibroblast. Fibroblasts play an important role in wound healing. Moreover, fibroblasts are capable of differentiating into various other cell types in the connective tissue such as osteoblasts, chondroblasts, and collagenoblasts.

Key Areas Covered

1. What is Fibroblast
      – Definition, Features, Function
2. What is Fibrocyte
      – Definition, Features, Function
3. What are the Similarities Between Fibroblast and Fibrocyte
      – Outline of Common Features
4. What is the Difference Between Fibroblast and Fibrocyte
      – Comparison of Key Differences

Key Terms: Chondroblasts, Collagen, Collagenoblasts, Elastin, Fibroblast, Fibrocyte, Fibrosis, Mesenchymal Cells, Myofibroblasts, OsteoblastsDifference Between Fibroblast And Fibrocyte - Comparison Summary

What is Fibroblast

A fibroblast is an immature, fiber-producing cell found in the connective tissue. Fibroblasts are large flat cells, containing an oval shaped nucleus. They also consist of elongated structures, which protrude from the cell body. Therefore, the actual shape of a fibroblast can be spindle-shaped. Active fibroblasts comprise many endoplasmic reticula in their cytoplasm. Since the cytoplasm of fibroblasts is basophilic, it is stained in purplish blue by the H&E stain. Typically, primitive mesenchymal cells give rise to fibroblasts. In certain situations, epithelial cells may also give rise to fibroblasts through epithelial-mesenchymal transition (EMT). Fibroblasts maintain the structural integrity of connective tissues through the formation of the structural framework (stroma) of animal tissue. Fibroblasts secrete the components of the extracellular matrix such as collagen, glycosaminoglycans, reticular and elastin fibers, glycoproteins, and other extracellular macromolecules. This leads to isolation and repair of damaged tissues.

Main Difference - Fibroblast vs Fibrocyte

Figure 1: Fibroblasts

Fibroblasts display a remarkable ability to differentiate into the other members of the connective tissue cells family, such as osteoblasts, chondroblasts, and collagenoblasts. Fibroblasts play a critical role in wound healing as well. In a tissue injury, the nearby pericytes are differentiated into fibroblasts. These fibroblasts migrate into the place of injury or wound to form a large collagenous matrix. The contractile fibroblasts assist the contraction of the wound. The contractile fibroblasts are also called myofibroblasts. The alterations in the metabolism of fibroblasts may lead to wound healing defects such as fibrosis. The fibroblast cells in the mouse embryo are shown in figure 1.

What is Fibrocyte

The inactive form of fibroblast is known as fibrocyte. Fibrocytes can be considered as mesenchymal cells with a small cytoplasm. Fibrocytes contain a few rough endoplasmic reticulum. Therefore, fibrocytes produce fewer proteins. The blood-born cells, which leave the blood and enter the tissue to become fibroblasts are also called fibrocytes. Fibroblasts and fibrocytes in a connective tissue are shown in figure 2.

Difference Between Fibroblast and Fibrocyte

Figure 2: Fibroblasts and fibrocytes

Similarities Between Fibroblast and Fibrocyte

  • Fibroblasts and fibrocytes are derived from mesenchymal cells.
  • Both fibroblasts and fibrocytes are involved in the tissue repair.

Difference Between Fibroblast and Fibrocyte


Fibroblast: Fibroblast is an immature, fiber-producing cell found in the connective tissue.

Fibrocyte: Fibrocyte is an inactive mesenchymal cell, containing a smaller cytoplasm and fewer endoplasmic reticula.


Fibroblast: Fibroblasts can be considered the least specialized cell type in the connective tissue, which is capable of differentiating into several cell types such as osteoblasts, chondroblasts, and collagenoblasts.

Fibrocyte: Fibrocytes are the inactive form of fibroblasts.


Fibroblast: The cytoplasm of the fibroblasts is basophilic. Therefore, it is stained in purplish blue by the H&E stain.

Fibrocyte: The cytoplasm of fibrocyte is less basophilic compared to fibroblasts. Therefore, fibrocytes are stained in pale purple color.

Endoplasmic Reticulum

Fibroblast: Fibroblasts comprise many endoplasmic reticula.

Fibrocyte: Fibrocytes comprise fewer endoplasmic reticula.


Fibroblast and fibrocyte are two stages of fiber-producing cells in the connective tissue. A fibroblast is the active form whereas the fibrocyte is the inactive form. This is the main difference between fibroblast and fibrocyte. Fibroblasts contain a prominent cytoplasm along with many endoplasmic reticuli. Fibroblasts secrete collagens and other components of the extracellular matrix. Both fibroblasts and fibrocytes are involved in the tissue repair.


1. Paxton, Steve, Michelle Peckham, and Knibbs Adele. “The Leeds Histology Guide.” Histology Guide | Connective Tissue. N.p., 01 Jan. 1970. Web. .  03 Aug. 2017. 
2. “Fibrocyte.” Wikipedia. Wikimedia Foundation, 20 July 2017. Web. . 04 Aug. 2017.

Image Courtesy:

1. “NIH 3T3″ By SubtleGuest at English Wikipedia via
2. “408 Connective Tissue” Von OpenStax College – Anatomy & Physiology, Jun 19, 2013. () via

About the Author: Lakna

Lakna, a graduate in Molecular Biology & Biochemistry, is a Molecular Biologist and has a broad and keen interest in the discovery of nature related things

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